Developing long-acting growth hormone formulations
نویسندگان
چکیده
منابع مشابه
Long-Acting Therapies Will Expand Growth Hormone Deficiency Market.
Future therapies for growth hormone deficiency are expected to include long-acting formulations that may encourage increased use of and adherence to these products.
متن کاملGrowth Hormone Research Society perspective on the development of long-acting growth hormone preparations
OBJECTIVE The Growth Hormone (GH) Research Society (GRS) convened a workshop to address important issues regarding trial design, efficacy, and safety of long-acting growth hormone preparations (LAGH). PARTICIPANTS A closed meeting of 55 international scientists with expertise in GH, including pediatric and adult endocrinologists, basic scientists, regulatory scientists, and participants from ...
متن کاملTREATMENT OF PRECOCIOUS PUBERTY BY A LONG-ACTING GONADOTROPIN-RELEASING HORMONE ANALOGUE IN CHILDREN
The GnRH analogue has been shown to be effective in the treatment of precocious puberty when given as a daily subcutaneous injection. We studied the effectiveness of a long-acting GnRH analogue, Triptoreline, for the treatment of central precocity, by suppressing gonadotropin and estradiol secretion in three children with true precocious puberty. One month after single dose intramuscular i...
متن کاملA phase 2 trial of long-acting TransCon growth hormone in adult GH deficiency
TransCon growth hormone is a sustained-release human growth hormone prodrug under development in which unmodified growth hormone is transiently linked to a carrier molecule. It is intended as an alternative to daily growth hormone in the treatment of growth hormone deficiency. This was a multi-center, randomized, open-label, active-controlled trial designed to compare the safety (including tole...
متن کاملEfficacy of a long-acting growth hormone (GH) preparation in patients with adult GH deficiency.
CONTEXT Treatment of adult GH deficiency (AGHD) with daily injections of GH results in decreased adipose mass, increased lean body mass (LBM), increased bone mineral density, and improved quality of life. OBJECTIVE This study seeks to determine whether a depot preparation of GH given every 14 d would lead to comparable decreases in trunk adipose tissue as daily GH. DESIGN This open-label, r...
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ژورنال
عنوان ژورنال: Clinical Endocrinology
سال: 2013
ISSN: 0300-0664
DOI: 10.1111/cen.12240